Issue 10, 2005
From the journal:

Chemical Communications

Highly enantioselective dynamic kinetic resolution and desymmetrization processes by cyclocondensation of chiral aminoalcohols with racemic or prochiral δ-oxoacid derivatives†

Mercedes Amat,*a   Oriol Bassas,a   Miquel A. Pericàs,b   Mireia Pastób  and  Joan Bosch*a  

* Corresponding authors

a Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028-Barcelona, Spain
E-mail: amat@ub.edu, joanbosch@ub.edu
Fax: +34 93 4034539
Tel: +34 93 4024538

b Barcelona Science Park/Department of Organic Chemistry, University of Barcelona, 08028-Barcelona, Spain

Abstract

Cyclocondensation reactions of aminoalcohols 7 and 8 with racemic or prochiral δ-oxoacid derivatives provide polysubstituted lactams with high enantioselectivity in a process that involves dynamic kinetic resolution and/or desymmetrization of enantiotopic or diastereotopic ester groups.

Graphical abstract: Highly enantioselective dynamic kinetic resolution and desymmetrization processes by cyclocondensation of chiral aminoalcohols with racemic or prochiral δ-oxoacid derivatives

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Article information

DOI
https://doi.org/10.1039/B413937B
Article type
Communication
Submitted
10 Sep 2004
Accepted
01 Dec 2004
First published
20 Jan 2005

Chem. Commun., 2005, 1327-1329

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Highly enantioselective dynamic kinetic resolution and desymmetrization processes by cyclocondensation of chiral aminoalcohols with racemic or prochiral δ-oxoacid derivatives

M. Amat, O. Bassas, M. A. Pericàs, M. Pastó and J. Bosch, Chem. Commun., 2005, 1327 DOI: 10.1039/B413937B

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