Straightforward detection of the secondary ionisation of the phosphate group and pK determinations by high-resolution solid-state 31P NMR

Carole Gardiennet; Bernard Henry; Paul Kuad; Bernard Spiess; Piotr Tekely

doi:10.1039/B413415J

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Straightforward detection of the secondary ionisation of the phosphate group and pK determinations by high-resolution solid-state ³¹P NMR†

Carole Gardiennet,^a Bernard Henry,^a Paul Kuad,^b Bernard Spiess^b and Piotr Tekely*^a

Author affiliations

* Corresponding authors

^a UMR CNRS 7565, Université Henri Poincaré, Nancy 1, 54506 Vandoeuvre-lès-Nancy, France
E-mail: Piotr.Tekely@rmn.uhp-nancy.fr
Fax: +33 383684347
Tel: +33 383684352

^b UMR CNRS 7081, Faculté de Pharmacie, Université Louis Pasteur, 67401 Illkirch, France

Abstract

The suitability of high-resolution solid-state ³¹P NMR for a straightforward determination of the protonation state of phosphate groups as well as of their pK₂ values extracted from solid state mono ∶ dianionic ratios has been demonstrated.

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Supplementary files

³¹P NMR values of the CSA tensor elements and corresponding parameters for L o-phosphoserine and AMP-5″ as a function of pH PDF (120K)

Article information

DOI: https://doi.org/10.1039/B413415J
Article type: Communication
Submitted: 02 Sep 2004
Accepted: 23 Sep 2004
First published: 25 Oct 2004

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Chem. Commun., 2005, 180-182

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Straightforward detection of the secondary ionisation of the phosphate group and pK determinations by high-resolution solid-state ³¹P NMR

C. Gardiennet, B. Henry, P. Kuad, B. Spiess and P. Tekely, Chem. Commun., 2005, 180 DOI: 10.1039/B413415J

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