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Issue 2, 2005
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“Polar patch” proteases as glycopeptiligases

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Abstract

The strategy of combined site directed mutagenesis and chemical modification with polar prosthetic groups was used to broaden substrate specificity of proteases resulting in the first successful formation of glycopeptides through the use of glucoamino acid acyl donors in yields of up to 90%.

Graphical abstract: “Polar patch” proteases as glycopeptiligases

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Publication details

The article was received on 05 Aug 2004, accepted on 24 Sep 2004 and first published on 03 Dec 2004


Article type: Communication
DOI: 10.1039/B412030B
Citation: Chem. Commun., 2005,0, 168-170

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    “Polar patch” proteases as glycopeptiligases

    K. J. Doores and B. G. Davis, Chem. Commun., 2005, 0, 168
    DOI: 10.1039/B412030B

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