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Issue 14, 2004
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Peribysins A–D, potent cell-adhesion inhibitors from a sea hare-derived culture of Periconia species

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Abstract

Peribysins A–D 1–4, including a new type of furanofuran, have been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai, and their relative stereostructures have been elucidated on the basis of NMR spectral analyses. All these metabolites potently inhibited the adhesion of human-leukemia HL-60 cells to HUVEC. The activity of compound 4, exhibiting the most potent inhibitory activity, was 380 times as potent as herbimycin A (standard).

Graphical abstract: Peribysins A–D, potent cell-adhesion inhibitors from a sea hare-derived culture of Periconia species

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Publication details

The article was received on 26 Mar 2004, accepted on 01 Jun 2004 and first published on 30 Jun 2004


Article type: Paper
DOI: 10.1039/B404459B
Citation: Org. Biomol. Chem., 2004,2, 2131-2135
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    Peribysins A–D, potent cell-adhesion inhibitors from a sea hare-derived culture of Periconia species

    T. Yamada, M. Iritani, K. Minoura, K. Kawai and A. Numata, Org. Biomol. Chem., 2004, 2, 2131
    DOI: 10.1039/B404459B

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