Issue 22, 2004
From the journal:

Organic & Biomolecular Chemistry

Synthesis of ring-oxidized retinoids as substrates of mouse class I alcohol dehydrogenase (ADH1)

Marta Domínguez,a   Rosana Alvarez,a   Sílvia Martras,b   Jaume Farrés,b   Xavier Parésb  and  Angel R. de Lera*a  

* Corresponding authors

a Departamento de Química Orgánica, Universidade de Vigo, Vigo, Spain
E-mail: qolera@usc.es
Fax: 34-986-812556
Tel: 34-986-812316

b Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain

Abstract

Ring-oxidized retinoids have been synthesized stereoselectively using the Stille cross-coupling reaction. Kinetic constants of mouse class I alcohol dehydrogenase (ADH1) with these retinoids were determined.

Graphical abstract: Synthesis of ring-oxidized retinoids as substrates of mouse class I alcohol dehydrogenase (ADH1)

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Article information

DOI
https://doi.org/10.1039/B411585F
Article type
Paper
Submitted
29 Jul 2004
Accepted
15 Sep 2004
First published
11 Oct 2004

Org. Biomol. Chem., 2004,2, 3368-3373

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Synthesis of ring-oxidized retinoids as substrates of mouse class I alcohol dehydrogenase (ADH1)

M. Domínguez, R. Alvarez, S. Martras, J. Farrés, X. Parés and A. R. de Lera, Org. Biomol. Chem., 2004, 2, 3368 DOI: 10.1039/B411585F

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