Issue 17, 2004
From the journal:

Organic & Biomolecular Chemistry

Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase—a key enzyme in M. tuberculosis cell wall biosynthesis†

Sylvaine Cren,a   Sudagar S. Gurcha,b   Alexander J. Blake,a   Gurdyal S. Besrab  and  Neil R. Thomas*a  

* Corresponding authors

a School of Chemistry, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, UK
E-mail: neil.thomas@nottingham.ac.uk

b School of Biosciences, University of Birmingham, Birmingham, UK

Abstract

Two iminosugars have been designed and synthesized as potential inhibitors of UDP-Galf transferase, an enzyme involved in Mycobacterium tuberculosis cell wall biosynthesis. The design is based on a proposed model of the transition state for the transferase reaction. One of the two racemic compounds is the first reported inhibitor of the target enzyme from M. smegmatis.

Graphical abstract: Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase—a key enzyme in M. tuberculosis cell wall biosynthesis

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Article information

DOI
https://doi.org/10.1039/B411554F
Article type
Communication
Submitted
09 Jun 2004
Accepted
30 Jul 2004
First published
09 Aug 2004

Org. Biomol. Chem., 2004,2, 2418-2420

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Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase—a key enzyme in M. tuberculosis cell wall biosynthesis

S. Cren, S. S. Gurcha, A. J. Blake, G. S. Besra and N. R. Thomas, Org. Biomol. Chem., 2004, 2, 2418 DOI: 10.1039/B411554F

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