Issue 14, 2004
From the journal:

Organic & Biomolecular Chemistry

The first aminoacylase-catalyzed enantioselective synthesis of aromatic β-amino acids

Harald Gröger,*a   Harald Trauthwein,*b   Stefan Buchholz,a   Karlheinz Drauz,c   Christiane Sacherer,b   Sylvie Godfrina  and  Helge Wernera  

* Corresponding authors

a Degussa AG, Service Center Biocatalysis, P. O. Box 1345, 63403 Hanau, Germany
E-mail: harald.groeger@degussa.com
Fax: +49 (0)6181 592961
Tel: +49 (0)6181 596401

b Degussa AG, Project House Catalysis, Industriepark Höchst, Building G 830, 65926 Frankfurt am Main, Germany
E-mail: harald.trauthwein@degussa.com
Fax: +49 (0)69 305 27338
Tel: +49 (0)69 305 17413

c Degussa AG, BU Fine Chemicals, FC-TRM, P. O. Box 1345, 63403 Hanau, Germany

Abstract

The first aminoacylase-catalyzed enantioselective synthesis of aromatic β-amino acids is reported. The presence of an N-chloroacetyl group as acyl group in the substrate as well as the use of porcine kidney acylase I as a suitable enzyme component are prerequisites for this resolution process whereby optically active β-amino acids are formed with high enantioselectivities of >98% ee.

Graphical abstract: The first aminoacylase-catalyzed enantioselective synthesis of aromatic β-amino acids

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Article information

DOI
https://doi.org/10.1039/B406380E
Article type
Communication
Submitted
28 Apr 2004
Accepted
02 Jun 2004
First published
29 Jun 2004

Org. Biomol. Chem., 2004,2, 1977-1978

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The first aminoacylase-catalyzed enantioselective synthesis of aromatic β-amino acids

H. Gröger, H. Trauthwein, S. Buchholz, K. Drauz, C. Sacherer, S. Godfrin and H. Werner, Org. Biomol. Chem., 2004, 2, 1977 DOI: 10.1039/B406380E

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