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Issue 13, 2004
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A short synthesis of (±)-cytisine

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Abstract

The synthesis of racemic cytisine 1 has been completed using (i)N-selective alkylation of 6-bromopyridone with bromide 6 and (ii) Pd(0) mediated intramolecular α-arylation of lactam 8 as key steps to achieve rapid assembly of the tricyclic core skeleton of the lupin alkaloids.

Graphical abstract: A short synthesis of (±)-cytisine

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Supplementary files

Article information


Submitted
07 Apr 2004
Accepted
07 May 2004
First published
04 Jun 2004

Org. Biomol. Chem., 2004,2, 1825-1826
Article type
Communication

A short synthesis of (±)-cytisine

C. Botuha, C. M. S. Galley and T. Gallagher, Org. Biomol. Chem., 2004, 2, 1825 DOI: 10.1039/B405275G

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