A short synthesis of (±)-cytisine†
Abstract
The synthesis of racemic cytisine 1 has been completed using (i)N-selective alkylation of 6-bromopyridone with bromide 6 and (ii) Pd(0) mediated intramolecular α-arylation of lactam 8 as key steps to achieve rapid assembly of the tricyclic core skeleton of the lupin alkaloids.