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Issue 6, 2004
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Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya

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Abstract

Covering: the literature from 2000–2004

This review outlines the recent developments in uncovering the enzymes and intermediates involved in fluorometabolite biosynthesis in the bacterium Streptomyces cattleya. A particular emphasis is placed on the purification and characterisation of the fluorinase, the C–F bond forming enzyme which initiates the biosynthesis. Nature has hardly developed a biochemistry around fluorine, yet fluorinated organics are important commercial entities, therefore a biotransformation from inorganic to organic fluorine is novel and of contemporary interest.

Graphical abstract: Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya

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Publication details

The article was received on 29 Sep 2004 and first published on 28 Oct 2004


Article type: Review Article
DOI: 10.1039/B415087M
Citation: Nat. Prod. Rep., 2004,21, 773-784

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    Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya

    H. Deng, D. O'Hagan and C. Schaffrath, Nat. Prod. Rep., 2004, 21, 773
    DOI: 10.1039/B415087M

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