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Issue 5, 2004
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“Microcanals” for micropipette access to single cells in microfluidic environments

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Abstract

We demonstrate the fabrication and operation of “microcanals” (i.e. open-air microfluidic channels without a roof), which enable micropipette manipulation and probing of cells within a microfluidic environment. The microcanal devices are fabricated in PDMS on glass substrates using a PDMS membrane transferring technique. Here we show patch-clamp electrophysiological recording and intracellular dye injection performed on cells seeded in microcanals.

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Publication details

The article was received on 01 Apr 2004, accepted on 26 Apr 2004 and first published on 23 Jul 2004


Article type: Paper
DOI: 10.1039/B404956J
Citation: Lab Chip, 2004,4, 420-424
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    “Microcanals” for micropipette access to single cells in microfluidic environments

    C. Hsu, C. Chen and A. Folch, Lab Chip, 2004, 4, 420
    DOI: 10.1039/B404956J

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