Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 3, 2004
Previous Article Next Article

Aggregation of bead-monolayers in flat microfluidic chambers – simulation by the model of porous media

Author affiliations


In this paper, we for the first time simulate the process of hydrodynamic bead aggregation in a flat micro-fluidic chamber by a porous-media model in an iterative routine. This allows us to optimize the chamber design of our recently developed experimental method to form periodical monolayers from the flow of bead suspension. Periodical monolayers are advantageous for parallel assay formats since they enhance the mechanical rigidity of the aggregated pattern. This is important to avoid a spatial rearrangement along various steps of a read-out procedure which would impair the correlation between measurements. Furthermore, the monolayer formation guarantees the individual optical accessibility of all probe beads. By modelling the monolayers with porous media, we can drastically reduce the degrees of freedom in a two-phase, multi-particle problem. This way, we are able to compute stationary hydrodynamic flow patterns in the chamber. In order to simulate the complete filling process from these stationary solutions, we developed an iterative master routine which takes the transient aggregation pattern as the initial condition, then evaluates the placement of the newly introduced beads, and finally converts the points of aggregation into porous media.

Back to tab navigation

Publication details

The article was received on 24 Oct 2003, accepted on 16 Dec 2003 and first published on 09 Feb 2004

Article type: Paper
DOI: 10.1039/B313432F
Citation: Lab Chip, 2004,4, 209-213

  •   Request permissions

    Aggregation of bead-monolayers in flat microfluidic chambers – simulation by the model of porous media

    M. Grumann, M. Dobmeier, P. Schippers, T. Brenner, C. Kuhn, M. Fritsche, R. Zengerle and J. Ducrée, Lab Chip, 2004, 4, 209
    DOI: 10.1039/B313432F

Search articles by author