Issue 9, 2004
From the journal:

Green Chemistry

Dynamic kinetic resolution of secondary alcohols by enzyme–metal combinations in ionic liquid†

Mahn-Joo Kim,*a   Hyun Min Kim,a   Daeho Kim,a   Yangsoo Ahna  and  Jaiwook Park*a  

* Corresponding authors

a National Research Laboratory of Chirotechnology, Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk 790-784, Korea
E-mail: mjkim@postech.ac.kr, pjw@postech.ac.kr
Fax: +82-54-279-0654

Abstract

Dynamic kinetic resolutions (DKRs) of secondary alcohols by lipase–ruthenium or subtilisin–ruthenium combo-catalysis were successfully accomplished in an ionic liquid, [BMIM]PF6 ([BMIM] = 1-butyl-3-methylimidazolium), in the presence of an acyl donor to provide (R)- or (S)-esters of high optical purities in good yields. Ionic liquid as solvent was essential for the successful performance of the DKRs at room temperature since its use enhanced the activity of the racemizing ruthenium catalyst.

Graphical abstract: Dynamic kinetic resolution of secondary alcohols by enzyme–metal combinations in ionic liquid

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Article information

DOI
https://doi.org/10.1039/B405651E
Article type
Paper
Submitted
15 Apr 2004
Accepted
27 Jul 2004
First published
23 Aug 2004

Green Chem., 2004,6, 471-474

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Dynamic kinetic resolution of secondary alcohols by enzyme–metal combinations in ionic liquid

M. Kim, H. M. Kim, D. Kim, Y. Ahn and J. Park, Green Chem., 2004, 6, 471 DOI: 10.1039/B405651E

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