Jump to main content
Jump to site search

Issue 2, 2004
Previous Article Next Article

Current progress in the asymmetric aldol addition reaction

Author affiliations


Control of stereochemistry during aldol addition reactions has attracted considerable interest over the years as the aldol reaction is one of the most fundamental tools for the construction of new carbon–carbon bonds. Several strategies have been implemented whereby eventually any single possible stereoisomeric aldol product can be accessed by choosing the appropriate procedure. With earlier methods, stoichiometric quantities of chiral reagents were required for efficient asymmetric induction, with the auxiliary most often attached covalently to the substrate carbonyl. Lewis acid catalyzed addition reactions of silyl enolates to aldehydes (Mukaiyama reaction) later opened the way for catalytic asymmetric induction. In the last few years, both chiral metal complexes and small chiral organic molecules have been found to catalyse the direct aldol addition of unmodified ketones to aldehydes with relatively high chemical and stereochemical efficiency. These techniques along with the more recent developments in the area are discussed in this tutorial review.

Graphical abstract: Current progress in the asymmetric aldol addition reaction

Back to tab navigation

Publication details

The article was received on 15 Jul 2003 and first published on 20 Jan 2004

Article type: Tutorial Review
DOI: 10.1039/B202901D
Citation: Chem. Soc. Rev., 2004,33, 65-75

  •   Request permissions

    Current progress in the asymmetric aldol addition reaction

    C. Palomo, M. Oiarbide and J. M. García, Chem. Soc. Rev., 2004, 33, 65
    DOI: 10.1039/B202901D

Search articles by author