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Issue 82, 2004

High-pressure recrystallisation—a route to new polymorphs and solvates

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Abstract

The recrystallisation of organic compounds from solution under high-pressure conditions is shown to be a versatile method for the formation of new polymorphs and solvates. The technique is illustrated by the crystallisation of a new polymorph of phenanthrene from dichloromethane at a pressure of 0.7 GPa, and the crystallisation of a novel dihydrate of paracetamol from water at a pressure of 1.1 GPa. These phases have been characterised by single crystal X-ray diffraction. We also demonstrate that the technique can be used to prepare a polymorph that is metastable under ambient conditions. Thus the orthorhombic form of paracetamol was crystallised from ethanol at a pressure of 1.1 GPa.

Graphical abstract: High-pressure recrystallisation—a route to new polymorphs and solvates

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Publication details

The article was received on 04 May 2004, accepted on 06 Jul 2004 and first published on 17 Sep 2004


Article type: Paper
DOI: 10.1039/B406631F
Citation: CrystEngComm, 2004,6, 505-511
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    High-pressure recrystallisation—a route to new polymorphs and solvates

    F. P. A. Fabbiani, D. R. Allan, W. I. F. David, S. A. Moggach, S. Parsons and C. R. Pulham, CrystEngComm, 2004, 6, 505
    DOI: 10.1039/B406631F

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