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Issue 17, 2004
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A single-enzyme, two-step, one-pot synthesis of N-substituted imidazole derivatives containing a glucose branch via combined acylation/Michael addition reaction

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Abstract

Combined regioselective acylation/Michael addition reaction catalyzed by alkaline protease from Bacillus subtilis in anhydrous pyridine for synthesis of N-substituted imidazole derivatives containing a glucose branch via a novel single-enzyme, two-step, one-pot procedure is reported.

Graphical abstract: A single-enzyme, two-step, one-pot synthesis of N-substituted imidazole derivatives containing a glucose branch via combined acylation/Michael addition reaction

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Publication details

The article was received on 19 Apr 2004, accepted on 17 Jun 2004 and first published on 29 Jul 2004


Article type: Communication
DOI: 10.1039/B405796A
Citation: Chem. Commun., 2004,0, 2006-2007

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    A single-enzyme, two-step, one-pot synthesis of N-substituted imidazole derivatives containing a glucose branch via combined acylation/Michael addition reaction

    S. Yao, D. Lu, Q. Wu, Y. Cai, S. Xu and X. Lin, Chem. Commun., 2004, 0, 2006
    DOI: 10.1039/B405796A

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