‘Double asymmetric induction’ as a novel tool for high stereocontrol in Baylis–Hillman reaction

Abstract

The strategy of double asymmetric induction was utilized in Baylis–Hillman reaction for the first time by the coupling of chiral aldehydes with chiral acrylate (1,2:5,6-di-O-isopropylidene-α-D-glucofuranose-3-acrylate) to obtain corresponding adducts with high syn diastereoselectivities (de >90%) in moderate to good yields.