Jump to main content
Jump to site search

Issue 20, 2004
Previous Article Next Article

Practical highly enantioselective synthesis of terminal propargylamines. An expeditious synthesis of (S)-(+)-coniine

Author affiliations

Abstract

The one-pot three-component addition reaction of trimethylsilylacetylene, aldehydes and dibenzylamine provides in the presence of CuBr/Quinap as catalyst, various enantiomerically enriched propargylamines in good yields (up to 99%) and excellent enantiomeric excess (up to 98% ee) which can be used as a key intermediate in the synthesis of the alkaloid (S)-(+)-coniine.

Graphical abstract: Practical highly enantioselective synthesis of terminal propargylamines. An expeditious synthesis of (S)-(+)-coniine

Back to tab navigation

Supplementary files

Article information


Submitted
02 Jul 2004
Accepted
23 Jul 2004
First published
07 Sep 2004

Chem. Commun., 2004, 2324-2325
Article type
Communication

Practical highly enantioselective synthesis of terminal propargylamines. An expeditious synthesis of (S)-(+)-coniine

N. Gommermann and P. Knochel, Chem. Commun., 2004, 2324
DOI: 10.1039/B409951F

Social activity

Search articles by author

Spotlight

Advertisements