Issue 18, 2004
From the journal:

Chemical Communications

Dual role for phenylalanine 178 during catalysis by aristolochene synthase†

Silvia Forcata  and  Rudolf K. Allemann*a  

* Corresponding authors

a School of Chemistry, University of Birmingham, Edgbaston, Birmingham, UK
E-mail: r.k.allemann@bham.ac.uk
Fax: +44 121 414 7871
Tel: 44 121 414 4359

Abstract

A mutant of aristolochene synthase, in which Phe 178 was replaced by Val, produced significant amounts of α- and β-farnesene as well as α and β-selinene and selina-4,11-diene, suggesting that Phe 178 is involved in the stabilisation of transition states preceding germacrene A and following eudesmane cation.

Graphical abstract: Dual role for phenylalanine 178 during catalysis by aristolochene synthase

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Article information

DOI
https://doi.org/10.1039/B407932A
Article type
Communication
Submitted
07 Jun 2004
Accepted
30 Jun 2004
First published
06 Aug 2004

Chem. Commun., 2004, 2094-2095

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Dual role for phenylalanine 178 during catalysis by aristolochene synthase

S. Forcat and R. K. Allemann, Chem. Commun., 2004, 2094 DOI: 10.1039/B407932A

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