Issue 20, 2004
From the journal:

Chemical Communications

High-efficiency and minimum-waste continuous kinetic resolution of racemic alcohols by using lipase in supercritical carbon dioxide†

Tomoko Matsuda,*a   Kazunori Watanabe,a   Tadao Harada,a   Kaoru Nakamura,b   Yoshitaka Arita,c   Yukihiro Misumi,c   Shinichiro Ichikawac  and  Takao Ikariya*d  

* Corresponding authors

a Department of Materials Chemistry, Ryukoku University, Otsu, Shiga 520-2194, Japan

b Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan

c Joint Research Center for Supercritical Fluids, Japan Chemical Innovation Institute (JCII), Tokyo Institute of Technology 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan

d Graduate School of Science and Engineering and Frontier Collaborative Research Center, Tokyo Institute of Technology 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan

Abstract

A novel continuous-flow scCO2 process for kinetic resolution of racemic alcohols can be performed with an immobilized lipase to lead to a quantitative mixture of the corresponding optically active acetates with up to 99% ee and unreacted alcohols with up to 99% ee, in which the productivity of the optically active compounds was improved by over 400 times compared to the corresponding batch reaction using scCO2.

Graphical abstract: High-efficiency and minimum-waste continuous kinetic resolution of racemic alcohols by using lipase in supercritical carbon dioxide

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Article information

DOI
https://doi.org/10.1039/B406882C
Article type
Communication
Submitted
10 May 2004
Accepted
06 Jul 2004
First published
26 Aug 2004

Chem. Commun., 2004, 2286-2287

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High-efficiency and minimum-waste continuous kinetic resolution of racemic alcohols by using lipase in supercritical carbon dioxide

T. Matsuda, K. Watanabe, T. Harada, K. Nakamura, Y. Arita, Y. Misumi, S. Ichikawa and T. Ikariya, Chem. Commun., 2004, 2286 DOI: 10.1039/B406882C

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