Issue 13, 2004
From the journal:

Chemical Communications

A novel one-pot four-component access to tetrahydro-β-carbolines by a coupling-amination-aza-annulation-Pictet–Spengler sequence (CAAPS)†

Alexei S. Karpov,a   Thomas Oesera  and  Thomas J. J. Müller*a  

* Corresponding authors

a Organisch-Chemisches Institut der Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg, Germany
E-mail: Thomas_J.J.Mueller@urz.uni-heidelberg.de
Fax: ++49(0)6221546579
Tel: ++49(0)6221546207

Abstract

The four-component coupling-amination-aza-annulation-Pictet–Spengler (CAAPS) sequence of acid chlorides 1, terminal alkynes 2, tryptamine derivatives 6, and acryloyl chloride derivatives 4 represents a facile and rapid one-pot access to tetrahydro-β-carbolines 7 in moderate to good yields.

Graphical abstract: A novel one-pot four-component access to tetrahydro-β-carbolines by a coupling-amination-aza-annulation-Pictet–Spengler sequence (CAAPS)

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Article information

DOI
https://doi.org/10.1039/B404559A
Article type
Communication
Submitted
29 Mar 2004
Accepted
27 Apr 2004
First published
25 May 2004

Chem. Commun., 2004, 1502-1503

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A novel one-pot four-component access to tetrahydro-β-carbolines by a coupling-amination-aza-annulation-Pictet–Spengler sequence (CAAPS)

A. S. Karpov, T. Oeser and T. J. J. Müller, Chem. Commun., 2004, 1502 DOI: 10.1039/B404559A

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