Issue 15, 2004
From the journal:

Chemical Communications

Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation†

Akira Otaka,*a   Satoshi Ueda,a   Kenji Tomita,a   Yoshiaki Yano,a   Hirokazu Tamamura,a   Katsumi Matsuzakia  and  Nobutaka Fujiia  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606–8501, Japan
E-mail: aotaka@pharm.kyoto-u.ac.jp
Fax: 81-75-753-4570
Tel: 81-75-753-4571

Abstract

Lipid bilayer-assisted chemical ligation between thiolester and N-terminal cysteine peptides has been developed with successful application to the synthesis of membrane protein segments possessing both two transmembrane and one extracellular regions.

Graphical abstract: Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation

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Article information

DOI
https://doi.org/10.1039/B404008B
Article type
Communication
Submitted
17 Mar 2004
Accepted
28 May 2004
First published
28 Jun 2004

Chem. Commun., 2004, 1722-1723

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Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation

A. Otaka, S. Ueda, K. Tomita, Y. Yano, H. Tamamura, K. Matsuzaki and N. Fujii, Chem. Commun., 2004, 1722 DOI: 10.1039/B404008B

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