Issue 15, 2004
From the journal:

Chemical Communications

Intramolecular C–H insertions adjacent to sulfur for the diastereoselective synthesis of thienofuranones

Paul S. Skerry,a   Nigel A. Swain,a   David C. Harrowven,*a   Donald Smyth,b   Gordon Brutonc  and  Richard C. D. Brown*a  

* Corresponding authors

a Department of Chemistry, University of Southampton, Southampton, UK
E-mail: rcb1@soton.ac.uk, dch2@soton.ac.uk
Fax: +44 (0)23 8059 6805
Tel: +44 (0)23 8059 4108

b OSI Pharmaceuticals, Watlington Road, Oxford, UK

c GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Harlow Essex, UK

Abstract

A new approach to the diastereoselective synthesis of thienofuranones is described in which an intramolecular 1,5-carbenoid C–H insertion adjacent to sulfur features as a key step.

Graphical abstract: Intramolecular C–H insertions adjacent to sulfur for the diastereoselective synthesis of thienofuranones

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Article information

DOI
https://doi.org/10.1039/B402603A
Article type
Communication
Submitted
20 Feb 2004
Accepted
26 May 2004
First published
30 Jun 2004

Chem. Commun., 2004, 1772-1773

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Intramolecular C–H insertions adjacent to sulfur for the diastereoselective synthesis of thienofuranones

P. S. Skerry, N. A. Swain, D. C. Harrowven, D. Smyth, G. Bruton and R. C. D. Brown, Chem. Commun., 2004, 1772 DOI: 10.1039/B402603A

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