Issue 10, 2004
From the journal:

Chemical Communications

Stereochemistry of hydrogen removal from the ‘unactivated’ C-3 position of 4-hydroxybutyryl-CoA catalysed by 4-hydroxybutyryl-CoA dehydratase

Richard Scott,a   Ulrike Näser,a   Peter Friedrich,a   Thorsten Selmer,b   Wolfgang Buckelb  and  Bernard T. Golding*a  

* Corresponding authors

a School of Natural Sciences – Chemistry, University of Newcastle upon Tyne, Bedson Building, Newcastle upon Tyne, UK
E-mail: b.t.golding@ncl.ac.uk

b Laboratorium für Mikrobiologie, Fachbereich Biologie, Phillips-Universität, Marburg D-35032, Germany

Abstract

(R)- and (S)-γ-[3-2H1]butyrolactones have been synthesised from (R)- and (S)-glycidol, respectively, and used to demonstrate that it is the pro-(S) hydrogen atom that is stereospecifically abstracted from C-3 of 4-hydroxybutyryl-CoA by 4-hydroxybutyryl-CoA dehydratase, and that this atom is not returned to C-4.

Graphical abstract: Stereochemistry of hydrogen removal from the ‘unactivated’ C-3 position of 4-hydroxybutyryl-CoA catalysed by 4-hydroxybutyryl-CoA dehydratase

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B402322F
Article type
Communication
Submitted
16 Feb 2004
Accepted
22 Mar 2004
First published
23 Apr 2004

Chem. Commun., 2004, 1210-1211

Permissions

Request permissions

Stereochemistry of hydrogen removal from the ‘unactivated’ C-3 position of 4-hydroxybutyryl-CoA catalysed by 4-hydroxybutyryl-CoA dehydratase

R. Scott, U. Näser, P. Friedrich, T. Selmer, W. Buckel and B. T. Golding, Chem. Commun., 2004, 1210 DOI: 10.1039/B402322F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements