Issue 5, 2004
From the journal:

Chemical Communications

Nucleic acid binding properties of thyminyl and adeninyl pyrrolidine-amideoligonucleotide mimics (POM)†

T. H. Samuel Tan,a   David T. Hickman,a   Jordi Morral,a   Ian G. Beadhama  and  Jason Micklefield*a  

* Corresponding authors

a Department of Chemistry, University of Manchester Institute of Science and Technology, PO Box 88, Manchester, UK
E-mail: jason.micklefield@umist.ac.uk
Fax: 0161 236 7677
Tel: 0161 200 4509

Abstract

Adeninyl POM was prepared using solid-phase peptide chemistry and shown to exhibit higher affinity for complementary DNA and RNA than the corresponding adeninyl PNA.

Graphical abstract: Nucleic acid binding properties of thyminyl and adeninyl pyrrolidine-amide oligonucleotide mimics (POM)

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Article information

DOI
https://doi.org/10.1039/B315768G
Article type
Communication
Submitted
03 Dec 2003
Accepted
22 Dec 2003
First published
28 Jan 2004

Chem. Commun., 2004, 516-517

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Nucleic acid binding properties of thyminyl and adeninyl pyrrolidine-amide oligonucleotide mimics (POM)

T. H. S. Tan, D. T. Hickman, J. Morral, I. G. Beadham and J. Micklefield, Chem. Commun., 2004, 516 DOI: 10.1039/B315768G

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