Issue 8, 2004
From the journal:

Chemical Communications

Absolute asymmetric synthesis by nucleophilic carbonyl addition using chiral crystals of achiral amides†

Masami Sakamoto,*a   Shuichiro Kobaru,a   Takashi Minoa  and  Tsutomu Fujitaa  

* Corresponding authors

a Department of Materials Technology, Faculty of Engineering, Chiba University, Yayoi-cho, Chiba 263-8522, Japan
E-mail: sakamotom@faculty.chiba-u.jp
Fax: 81 43 290 3401
Tel: 81 43 290 3387

Abstract

Reaction of the chiral crystals of the achiral amides with n-butyllithium in toluene at −80 °C gave optically active alcohols in 17–84% ee.

Graphical abstract: Absolute asymmetric synthesis by nucleophilic carbonyl addition using chiral crystals of achiral amides

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Article information

DOI
https://doi.org/10.1039/B315729F
Article type
Communication
Submitted
03 Dec 2003
Accepted
19 Feb 2004
First published
19 Mar 2004

Chem. Commun., 2004, 1002-1003

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Absolute asymmetric synthesis by nucleophilic carbonyl addition using chiral crystals of achiral amides

M. Sakamoto, S. Kobaru, T. Mino and T. Fujita, Chem. Commun., 2004, 1002 DOI: 10.1039/B315729F

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