Issue 3, 2004
From the journal:

Chemical Communications

Parallel nucleic acid recognition by the LNA (locked nucleic acid) stereoisomers β-L-LNA and α-D-LNA; studies in the mirror image world

Nanna K. Christensen,a   Torsten Bryld,a   Mads D. Sørensen,b   Khalil Arar,c   Jesper Wengela  and  Poul Nielsen*a  

* Corresponding authors

a Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK-5230 Odense, Denmark
E-mail: pon@chem.sdu.dk

b Department of Chemistry, University of Copenhagen, DK-2100 Copenhagen, Denmark

c Proligo, Rue Delaunay 1, Paris 75011, France

Abstract

Two LNA (locked nucleic acid) stereoisomers (β-L-LNA and α-D-LNA) are evaluated in the mirror-image world, that is by the study of two mixed sequences of LNA and α-L-LNA and their L-DNA and L-RNA complements. Both are found to display high-affinity RNA-recognition by the formation of duplexes with parallel strand orientation.

Graphical abstract: Parallel nucleic acid recognition by the LNA (locked nucleic acid) stereoisomers β-L-LNA and α-D-LNA; studies in the mirror image world

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Article information

DOI
https://doi.org/10.1039/B312321A
Article type
Communication
Submitted
03 Oct 2003
Accepted
03 Dec 2003
First published
19 Dec 2003

Chem. Commun., 2004, 282-283

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Parallel nucleic acid recognition by the LNA (locked nucleic acid) stereoisomers β-L-LNA and α-D-LNA; studies in the mirror image world

N. K. Christensen, T. Bryld, M. D. Sørensen, K. Arar, J. Wengel and P. Nielsen, Chem. Commun., 2004, 282 DOI: 10.1039/B312321A

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