Issue 3, 2004
From the journal:

Analyst

Ethyl glucoside in human urine following dietary exposure: detection by 1H NMR spectroscopy as a result of metabonomic screening of humans

Claire Teague,a   Elaine Holmes,a   Elaine Maibaum,a   Jeremy Nicholson,a   Huiru Tang,a   Queenie Chan,b   Paul Elliottb  and  Ian Wilson*ac  

* Corresponding authors

a Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, UK

b Department of Epidemiology and Public Health, Imperial College London, St Mary's, London, UK

c Drug Metabolism and Pharmacokinetics Department, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UK
E-mail: Ian.Wilson@astrazeneca.com

Abstract

Metabonomic screening of human urine samples using 1H NMR spectroscopy has revealed the presence of signals resulting from the excretion of ethyl glucoside. Experiments in volunteers have demonstrated that this ethyl glucoside results from dietary exposure to the compound, which is present in beverages such as rice wine and sake, rather than representing a new route for the metabolism of ethanol by humans. The limited studies undertaken in volunteers indicate that ethyl glucoside has a longer biological half life than ethanol itself. The potential problems associated with using this glucoside metabolite as a marker of ethanol consumption are considered.

About
Cited by
Related
Download options Please wait...

Additions and corrections

Article information

DOI
https://doi.org/10.1039/B314316N
Article type
Paper
Submitted
07 Nov 2003
Accepted
14 Jan 2004
First published
27 Jan 2004

Analyst, 2004,129, 259-264

Permissions

Request permissions

Ethyl glucoside in human urine following dietary exposure: detection by 1H NMR spectroscopy as a result of metabonomic screening of humans

C. Teague, E. Holmes, E. Maibaum, J. Nicholson, H. Tang, Q. Chan, P. Elliott and I. Wilson, Analyst, 2004, 129, 259 DOI: 10.1039/B314316N

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements