Issue 21, 2003

Glycosyl phenylthiosulfonates (Glyco-PTS): novel reagents for glycoprotein synthesis

Abstract

Controlled site-selective glycosylation can be achieved by combining site-directed cysteine mutagenesis with chemical modification of the introduced thiol; a new class of more efficient chemoselective reagents, glycosyl phenylthiosulfonates, allow rapid glycosylations of representative simple thiols, peptides and proteins.

Graphical abstract: Glycosyl phenylthiosulfonates (Glyco-PTS): novel reagents for glycoprotein synthesis

Supplementary files

Article information

Article type
Communication
Submitted
19 Jun 2003
Accepted
28 Jul 2003
First published
11 Aug 2003

Org. Biomol. Chem., 2003,1, 3642-3644

Glycosyl phenylthiosulfonates (Glyco-PTS): novel reagents for glycoprotein synthesis

D. P. Gamblin, P. Garnier, S. J. Ward, N. J. Oldham, A. J. Fairbanks and B. G. Davis, Org. Biomol. Chem., 2003, 1, 3642 DOI: 10.1039/B306990G

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