Issue 9, 2003
From the journal:

Organic & Biomolecular Chemistry

Stereochemistry and mechanism of the conversion of 5-aminolaevulinic acid into porphobilinogen catalysed by porphobilinogen synthase†

Catherine E. Goodwina  and  Finian J. Leeper*a  

* Corresponding authors

a University Chemical Laboratory, Lensfield Road, Cambridge, UK
E-mail: FJL1@cam.ac.uk

Abstract

(3R)- and (3S)-Deuteriated forms of 5-aminolaevulinic acid have been synthesised and the (3R)-form shows a significantly larger isotope effect when incubated with porphobilinogen synthase from bovine liver and from Bacillus subtilis; based on this and on available crystal structures, a modified mechanism for the enzymic reaction is proposed.

Graphical abstract: Stereochemistry and mechanism of the conversion of 5-aminolaevulinic acid into porphobilinogen catalysed by porphobilinogen synthase

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Article information

DOI
https://doi.org/10.1039/B302509H
Article type
Communication
Submitted
05 Mar 2003
Accepted
26 Mar 2003
First published
02 Apr 2003

Org. Biomol. Chem., 2003,1, 1443-1446

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Stereochemistry and mechanism of the conversion of 5-aminolaevulinic acid into porphobilinogen catalysed by porphobilinogen synthase

C. E. Goodwin and F. J. Leeper, Org. Biomol. Chem., 2003, 1, 1443 DOI: 10.1039/B302509H

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