Issue 4, 2003
From the journal:

Organic & Biomolecular Chemistry

Enzymatic optical resolution viaacylation–hydrolysis on a solid support

Rein V. Ulijn,a   Nicola Biseka  and  Sabine L. Flitsch*a  

* Corresponding authors

a School of Chemistry, The University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, UK
E-mail: s.flitsch@ed.ac.uk
Fax: + (0)131 650 4737
Tel: + (0)131 650 4737

Abstract

By taking advantage of the reversibility of the thermolysin-catalysed amide synthesis–hydrolysis reaction on a solid support, both L,L and L,D diastereoisomers of dipeptides and L-amino acids are accessible in good yields starting from enantiomeric mixtures of amino acids.

Graphical abstract: Enzymatic optical resolution via acylation–hydrolysis on a solid support

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Article information

DOI
https://doi.org/10.1039/B211887D
Article type
Communication
Submitted
04 Dec 2002
Accepted
17 Jan 2003
First published
28 Jan 2003

Org. Biomol. Chem., 2003,1, 621-622

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Enzymatic optical resolution via acylation–hydrolysis on a solid support

R. V. Ulijn, N. Bisek and S. L. Flitsch, Org. Biomol. Chem., 2003, 1, 621 DOI: 10.1039/B211887D

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