Issue 23, 2003
From the journal:

Organic & Biomolecular Chemistry

The syntheses of tricyclic analogues of O6-methylguanine

David M. Hammond,a   Dolorès Edmont,†a   Ana R. Hornillo-Araujoa  and  David M. Williams*a  

* Corresponding authors

a Centre for Chemical Biology, Department of Chemistry, Krebs Institute, University of Sheffield, Brook Hill, Sheffield, UK
E-mail: d.m.williams@sheffield.ac.uk
Fax: +44 (0)114 222 9346
Tel: +44 (0)114 222 9502

Abstract

The syntheses of the novel pyrrolo[2,3-d]pyrimidine-based heterocycles as tricyclic analogues of O6-methylguanine are described. Compound 5 is a weak inhibitor of human O6-alkylguanine DNA alkyltransferase.

Graphical abstract: The syntheses of tricyclic analogues of O6-methylguanine

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Article information

DOI
https://doi.org/10.1039/B309779J
Article type
Paper
Submitted
14 Aug 2003
Accepted
26 Sep 2003
First published
22 Oct 2003

Org. Biomol. Chem., 2003,1, 4166-4172

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The syntheses of tricyclic analogues of O6-methylguanine

D. M. Hammond, D. Edmont, A. R. Hornillo-Araujo and D. M. Williams, Org. Biomol. Chem., 2003, 1, 4166 DOI: 10.1039/B309779J

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