Issue 22, 2003

Amphotericin B–phospholipid covalent conjugates: dependence of membrane-permeabilizing activity on acyl-chain length

Abstract

The interaction between amphotericin B and phospholipid upon forming ion channels across a biomembrane was investigated using their covalent conjugates. The membrane permeabilizing activity was greatly affected by the chain length of the fatty acyl groups, suggesting that their interaction is involved in ion channel assemblages.

Graphical abstract: Amphotericin B–phospholipid covalent conjugates: dependence of membrane-permeabilizing activity on acyl-chain length

Article information

Article type
Communication
Submitted
18 Jun 2003
Accepted
07 Oct 2003
First published
13 Oct 2003

Org. Biomol. Chem., 2003,1, 3882-3884

Amphotericin B–phospholipid covalent conjugates: dependence of membrane-permeabilizing activity on acyl-chain length

S. Matsuoka, N. Matsumori and M. Murata, Org. Biomol. Chem., 2003, 1, 3882 DOI: 10.1039/B306801C

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