An improved synthesis of the 1,1′,2,2′,3,3′,4,4′-octahydro-1,1′-biisoquinoline ring system is described. The reactivity of this system has been investigated, including the unusually high basicity of the parent compound and its N,N′-dimethyl derivative. The resolution of the parent compound has been achieved for the first time, along with the development of a straightforward method for assaying its enantiomeric purity.
M. C. Elliott and E. Williams, Org. Biomol. Chem., 2003, 1, 3038 DOI: 10.1039/B306159K
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