Issue 18, 2003
From the journal:

Organic & Biomolecular Chemistry

The Co(i) induced methylmalonyl-succinyl rearrangement in a model for the coenzyme B12 dependent methylmalonyl-CoA mutase

Fangping Suna  and  Tamis Darbre*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern, Switzerland

Abstract

The rearrangement of 2-bromomethyl-2-methylmonothiomalonates to succinyl derivatives was found to take place in quantitative yields in the presence of one molar equivalent of Co(I) generated by the reduction of heptamethyl Co(II)yrinate perchlorate with NaBH4 or electrochemically. The chiral thiomalonate gave racemic succinate.

Graphical abstract: The Co(i) induced methylmalonyl-succinyl rearrangement in a model for the coenzyme B12 dependent methylmalonyl-CoA mutase

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Article information

DOI
https://doi.org/10.1039/B305782H
Article type
Paper
Submitted
27 May 2003
Accepted
15 Jul 2003
First published
11 Aug 2003

Org. Biomol. Chem., 2003,1, 3154-3159

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The Co(I) induced methylmalonyl-succinyl rearrangement in a model for the coenzyme B12 dependent methylmalonyl-CoA mutase

F. Sun and T. Darbre, Org. Biomol. Chem., 2003, 1, 3154 DOI: 10.1039/B305782H

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