Issue 17, 2003
From the journal:

Organic & Biomolecular Chemistry

Synthetic and structural studies on 1,2,4-dithiazolidine-3,5-dione derivatives

Mark E. Wood,*a   Daniel J. Cane-Honeysett,a   Michael D. Dowle,b   Simon J. Colesc  and  Michael B. Hursthousec  

* Corresponding authors

a School of Chemistry, University of Exeter, Stocker Road, Exeter, UK
E-mail: m.e.wood@exeter.ac.uk
Fax: 44 1392 263434
Tel: 44 1392 263450

b GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, UK

c EPSRC X-ray Crystallography Service, Department of Chemistry, University of Southampton, Highfield, Southampton, UK

Abstract

Methods have been developed for the N-alkylation of 1,2,4-dithiazolidine-3,5-dione 2 and the subsequent conversion of the N-alkylated derivatives into isocyanates 5. An extension of this methodology onto a solid-support is also reported. X-ray crystallographic analysis has been carried out on potassium 1,2,4-dithiazolidine-3,5-dione 3 for structural comparison with the parent heterocycle 2.

Graphical abstract: Synthetic and structural studies on 1,2,4-dithiazolidine-3,5-dione derivatives

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Article information

DOI
https://doi.org/10.1039/B305096C
Article type
Paper
Submitted
09 May 2003
Accepted
10 Jul 2003
First published
29 Jul 2003

Org. Biomol. Chem., 2003,1, 3015-3023

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Synthetic and structural studies on 1,2,4-dithiazolidine-3,5-dione derivatives

M. E. Wood, D. J. Cane-Honeysett, M. D. Dowle, S. J. Coles and M. B. Hursthouse, Org. Biomol. Chem., 2003, 1, 3015 DOI: 10.1039/B305096C

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