Issue 13, 2003
From the journal:

Organic & Biomolecular Chemistry

Potent and specific sialyltransferase inhibitors: imino-linked 5a′-carbadisaccharides

Kensuke Okazaki,a   Sachiko Nishigaki,b   Fumito Ishizuka,a   Yasuhiro Kajihara*b  and  Seiichiro Ogawa*a  

* Corresponding authors

a Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Hiyoshi, Yokohama, 223-8522, Japan

b Graduate School of Integrated Science, Yokohama City University, Seto, Yokohama, 236-0027, Japan

Abstract

Methyl 5a′-carba-β-lactoside, imino-linked, has been shown to possess potent and specific inhibitory activity (IC50 = 185 µM) toward rat recombinant α2,3-sialyltransferase.

Graphical abstract: Potent and specific sialyltransferase inhibitors: imino-linked 5a′-carbadisaccharides

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Article information

DOI
https://doi.org/10.1039/B304695H
Article type
Communication
Submitted
28 Apr 2003
Accepted
30 May 2003
First published
05 Jun 2003

Org. Biomol. Chem., 2003,1, 2229-2230

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Potent and specific sialyltransferase inhibitors: imino-linked 5a′-carbadisaccharides

K. Okazaki, S. Nishigaki, F. Ishizuka, Y. Kajihara and S. Ogawa, Org. Biomol. Chem., 2003, 1, 2229 DOI: 10.1039/B304695H

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