Issue 11, 2003
From the journal:

Organic & Biomolecular Chemistry

A pincer auxiliary to force difficult lactamisations†

Hans Bieräugel,a   Hans E. Schoemaker,b   Henk Hiemstraa  and  Jan H. van Maarseveen*a  

* Corresponding authors

a Institute of Molecular Chemistry, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands
E-mail: jvm@science.uva.nl

b DSM Research, Life Science Products, PO Box 18, 6160 MD Geleen, The Netherlands

Abstract

A new method to cyclise peptides is reported based on insertion of a salicylaldehyde derived pincer auxiliary in the linear precursor sequence. H-βAla-Phe-OH and H-Phe-βAla-OH were chosen as representative model peptides.

Graphical abstract: A pincer auxiliary to force difficult lactamisations

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Article information

DOI
https://doi.org/10.1039/B303836J
Article type
Communication
Submitted
07 Apr 2003
Accepted
07 May 2003
First published
13 May 2003

Org. Biomol. Chem., 2003,1, 1830-1832

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A pincer auxiliary to force difficult lactamisations

H. Bieräugel, H. E. Schoemaker, H. Hiemstra and J. H. van Maarseveen, Org. Biomol. Chem., 2003, 1, 1830 DOI: 10.1039/B303836J

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