Issue 16, 2003
From the journal:

Organic & Biomolecular Chemistry

Alkylation of manganese(ii) tetraphenylporphyrin by a synthetic antimalarialtrioxane

Jean-François Berrien,a   Olivier Provot,a   Joëlle Mayrargue,*a   Michel Coquillay,b   Liliane Cicéron,c   Frédérick Gay,c   Martin Danis,c   Anne Robertd  and  Bernard Meunier*d  

* Corresponding authors

a UMR 8076 BioCIS, Faculté de Pharmacie, rue J.-B. Clément, F-92296 Châtenay-Malabry Cedex, France
E-mail: Joelle.Mayrargue@chimorg.u-psud.fr

b Laboratoire de Physique, Faculté de Pharmacie, rue J.-B. Clément, F-92296 Châtenay-Malabry Cedex, France

c INSERM U511, Immuno-biologie cellulaire et moléculaire des infections parasitaires, Groupe hospitalier Pitié-Salpêtrière, F-75013 Paris, France

d Laboratoire de Chimie de Coordination du CNRS, 205, route de Narbonne, 31077 Toulouse Cedex 4, France

Abstract

The synthesis and the antimalarial activity of a new kind of polycyclic 1,2,4-trioxanes are reported. The alkylation of the heme model MnIITPP by the biologically active (IC 50 = 320 nmol L−1) hemiperketal 2 is presented.

Graphical abstract: Alkylation of manganese(ii) tetraphenylporphyrin by a synthetic antimalarial trioxane

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Article information

DOI
https://doi.org/10.1039/B302835F
Article type
Paper
Submitted
14 Mar 2003
Accepted
23 Jun 2003
First published
14 Jul 2003

Org. Biomol. Chem., 2003,1, 2859-2864

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Alkylation of manganese(II) tetraphenylporphyrin by a synthetic antimalarial trioxane

J. Berrien, O. Provot, J. Mayrargue, M. Coquillay, L. Cicéron, F. Gay, M. Danis, A. Robert and B. Meunier, Org. Biomol. Chem., 2003, 1, 2859 DOI: 10.1039/B302835F

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