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Issue 11, 2003
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Synthesis of 2,2-dimethyl-1,25-dihydroxyvitamin D3: A-ring structural motif that modulates interactions of vitamin D receptor with transcriptional coactivators

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Abstract

A concise synthesis of all four possible A-ring stereoisomers of 2,2-dimethyl-1,25-dihydroxyvitamin D3 and characterization of their distinct transcriptional features, which appear to have been inherited from the corresponding 2α-methyl derivatives, is reported.

Graphical abstract: Synthesis of 2,2-dimethyl-1,25-dihydroxyvitamin D3: A-ring structural motif that modulates interactions of vitamin D receptor with transcriptional coactivators

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Publication details

The article was received on 24 Feb 2003, accepted on 02 Apr 2003 and first published on 17 Apr 2003


Article type: Paper
DOI: 10.1039/B302017G
Org. Biomol. Chem., 2003,1, 1863-1869

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    Synthesis of 2,2-dimethyl-1,25-dihydroxyvitamin D3: A-ring structural motif that modulates interactions of vitamin D receptor with transcriptional coactivators

    T. Fujishima, A. Kittaka, K. Yamaoka, K. Takeyama, S. Kato and H. Takayama, Org. Biomol. Chem., 2003, 1, 1863
    DOI: 10.1039/B302017G

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