Issue 2, 2003
From the journal:

Organic & Biomolecular Chemistry

Total synthesis of (±)-rhazinal, an alkaloidal spindle toxin from Kopsia teoi

Martin G. Banwell,*a   Alison J. Edwards,a   Katrina A. Jolliffe,ab   Jason A. Smith,a   Ernest Hamelc  and  Pascal Verdier-Pinardc  

* Corresponding authors

a Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 0200, Australia
E-mail: mgb@rsc.anu.edu.au

b School of Chemistry, University of Sydney, NSW 2006, Australia

c Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA

Abstract

The title alkaloid 1 and its B-nor-congener 3, both of which display potent and unusual anti-mitotic properties, have been synthesized in racemic form and characterised by single-crystal X-ray analysis.

Graphical abstract: Total synthesis of (±)-rhazinal, an alkaloidal spindle toxin from Kopsia teoi

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Article information

DOI
https://doi.org/10.1039/B209992F
Article type
Paper
Submitted
14 Oct 2002
Accepted
11 Nov 2002
First published
19 Dec 2002

Org. Biomol. Chem., 2003,1, 296-305

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Total synthesis of (±)-rhazinal, an alkaloidal spindle toxin from Kopsia teoi

M. G. Banwell, A. J. Edwards, K. A. Jolliffe, J. A. Smith, E. Hamel and P. Verdier-Pinard, Org. Biomol. Chem., 2003, 1, 296 DOI: 10.1039/B209992F

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