Reactivity studies of 3-alkoxy-7-amino-4-chloroisocoumarins (β-amyloid peptideinhibitors) versus different classes of amines

Abstract

3-Alkoxy-7-amino-4-chloroisocoumarins have been shown to lower the β-amyloid secretion (a major component of the senile plaques involved in Alzheimer's disease). This paper reports the characterization of new adducts resulting from the reaction between the isocoumarin synthon and different classes of amines. This study allows on the one hand, a better understanding of the biological molecular processes by which such isocoumarin derivatives may interact with enzyme nucleophiles and, on the other hand, brings out the chemical potential of these synthons to generate new polycyclic derivatives.