Issue 1, 2003

Development of β-keto 1,3-dithianes as versatile intermediates for organic synthesis

Abstract

β-Keto 1,3-dithianes can be generated by the double conjugate addition of dithiols to propargylic ketones, esters and aldehydes in excellent yields. As masked 1,3-dicarbonyl systems these substrates can be converted to a range of functionalised oxygen-containing heterocycles that can be used in natural product synthesis.

Graphical abstract: Development of β-keto 1,3-dithianes as versatile intermediates for organic synthesis

Article information

Article type
Communication
Submitted
16 Sep 2002
Accepted
30 Oct 2002
First published
03 Dec 2002

Org. Biomol. Chem., 2003,1, 15-16

Development of β-keto 1,3-dithianes as versatile intermediates for organic synthesis

M. J. Gaunt, H. F. Sneddon, P. R. Hewitt, P. Orsini, D. F. Hook and S. V. Ley., Org. Biomol. Chem., 2003, 1, 15 DOI: 10.1039/B208982C

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