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Issue 10, 2003
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Synthesis and characterisation of ibuprofen-anchored MCM-41 silica and silica gel

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Abstract

A non-steroidal anti-inflammatory drug (ibuprofen) has been anchored inside the mesoporous channels of MCM-41-type silica and on a silica gel surface. The relevant anchoring procedure through an ester function has been investigated. It uses the epoxide ring opening of 3-glycidoxypropylsilane grafted on the silica surface by the carboxylic-group-containing ibuprofen. The control of the surface modification and of the anchoring efficiency was achieved by comparison of spectroscopic data with those obtained using homogeneous counterparts. The use of nanostructured silica allowed an accurate verification of the different surface modifications and also a higher drug loading.

Graphical abstract: Synthesis and characterisation of ibuprofen-anchored MCM-41 silica and silica gel

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Publication details

The article was received on 12 Jun 2003, accepted on 31 Jul 2003 and first published on 02 Sep 2003


Article type: Letter
DOI: 10.1039/B307046H
New J. Chem., 2003,27, 1415-1418

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    Synthesis and characterisation of ibuprofen-anchored MCM-41 silica and silica gel

    C. Tourné-Péteilh, D. Brunel, S. Bégu, B. Chiche, F. Fajula, D. A. Lerner and J. Devoisselle, New J. Chem., 2003, 27, 1415
    DOI: 10.1039/B307046H

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