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Issue 10, 2003
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Synthesis and characterisation of ibuprofen-anchored MCM-41 silica and silica gel

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Abstract

A non-steroidal anti-inflammatory drug (ibuprofen) has been anchored inside the mesoporous channels of MCM-41-type silica and on a silica gel surface. The relevant anchoring procedure through an ester function has been investigated. It uses the epoxide ring opening of 3-glycidoxypropylsilane grafted on the silica surface by the carboxylic-group-containing ibuprofen. The control of the surface modification and of the anchoring efficiency was achieved by comparison of spectroscopic data with those obtained using homogeneous counterparts. The use of nanostructured silica allowed an accurate verification of the different surface modifications and also a higher drug loading.

Graphical abstract: Synthesis and characterisation of ibuprofen-anchored MCM-41 silica and silica gel

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Article information


Submitted
12 Jun 2003
Accepted
31 Jul 2003
First published
02 Sep 2003

New J. Chem., 2003,27, 1415-1418
Article type
Letter

Synthesis and characterisation of ibuprofen-anchored MCM-41 silica and silica gel

C. Tourné-Péteilh, D. Brunel, S. Bégu, B. Chiche, F. Fajula, D. A. Lerner and J. Devoisselle, New J. Chem., 2003, 27, 1415
DOI: 10.1039/B307046H

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