Issue 8, 2003
From the journal:

New Journal of Chemistry

Molecular design of calcimycin (A23187) evidenced by the complexing behaviour of its 4-bromo and 19-demethyl analogues

Stéphane Vila,a   Isabelle Canet,*a   Jacques Guyot,a   Georges Jeminet*a  and  Yvon Pointudb  

* Corresponding authors

a Laboratoire de Synthèse et Etude de Systèmes à Intêret Biologique (CNRS UMR 6504), Université Blaise Pascal Clermont-Ferrand, Campus des Cézeaux, Aubière cedex, France
E-mail: isabelle.canet@chimie.univ-bpclermont.fr
Fax: +33 4 73 40 77 17

b Laboratoire de Thermodynamique des Solutions et des Polymères (CNRS UMR 6003), Université Blaise Pascal Clermont-Ferrand, Campus des Cézeaux, Aubière cedex, France

Abstract

An original comparison of the complexing properties of calcimycin (A23187) and its 4-bromo and 19-demethyl analogues with the alkaline earth cations, Mn2+ and Zn2+, gives new insight on the molecular design of this universally used calcium ionophore.

Graphical abstract: Molecular design of calcimycin (A23187) evidenced by the complexing behaviour of its 4-bromo and 19-demethyl analogues

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Article information

DOI
https://doi.org/10.1039/B300338H
Article type
Paper
Submitted
09 Jan 2003
Accepted
18 Mar 2003
First published
02 Jul 2003

New J. Chem., 2003,27, 1246-1250

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Molecular design of calcimycin (A23187) evidenced by the complexing behaviour of its 4-bromo and 19-demethyl analogues

S. Vila, I. Canet, J. Guyot, G. Jeminet and Y. Pointud, New J. Chem., 2003, 27, 1246 DOI: 10.1039/B300338H

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