Issue 4, 2003
From the journal:

Green Chemistry

The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions

L. El Kaïm,a   L. Gautier,a   L. Grimaud,a   L. M. Harwoodb  and  V. Michauta  

a Laboratoire Chimie et Procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75015 Paris, France
E-mail: elkaim@ensta.fr
Fax: +33 1 45 52 83 22

b Department of Chemistry, University of Reading, PO BOX224, Whiteknights, Reading, UK

Abstract

The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with p-nitro substituted arylhydrazones. These conditions allow the efficient coupling of simple hydrazones that failed to react in toluene or ethanol solutions.

Graphical abstract: The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions

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Article information

DOI
https://doi.org/10.1039/B306242B
Article type
Paper
Submitted
03 Jun 2003
First published
22 Jul 2003

Green Chem., 2003,5, 477-479

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The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions

L. E. Kaïm, L. Gautier, L. Grimaud, L. M. Harwood and V. Michaut, Green Chem., 2003, 5, 477 DOI: 10.1039/B306242B

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