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Issue 4, 2003
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The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions

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Abstract

The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with p-nitro substituted arylhydrazones. These conditions allow the efficient coupling of simple hydrazones that failed to react in toluene or ethanol solutions.

Graphical abstract: The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions

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Article information


Submitted
03 Jun 2003
First published
22 Jul 2003

Green Chem., 2003,5, 477-479
Article type
Paper

The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions

L. E. Kaïm, L. Gautier, L. Grimaud, L. M. Harwood and V. Michaut, Green Chem., 2003, 5, 477
DOI: 10.1039/B306242B

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