Rapid microwave-promoted Suzuki cross coupling reaction in water
Abstract
Water is an inexpensive and nontoxic reaction medium for the microwave-promoted Suzuki cross coupling of arylboronic acids with aryl halides. This environmentally friendly microwave protocol offers convenient operation and synthesis of a variety of substituted biaryls in good yield very rapidly employing PdCl2(PPh3)2 as catalyst and potassium carbonate as the base.