Clean synthesis of an array of N-benzoyl–N′-aryl ureas using polymer-supported reagents

Abstract

An efficient clean synthesis of an array of N-benzoyl–N′-aryl ureas using polymer-supported isothiocyanate and iodate as reagents and strong acidic ion-exchange resin as scavenger is described. Representative ureas were obtained with moderate to high yield and excellent purity. The process of the reaction and purity of the isolation were easily monitored by TLC or HPLC.