Metal complexes of a dipyridine octaazamacrocycle: stability constants, structural and modelling studies

Abstract

Two 28-membered octaazamacrocycles, [28]py₂N₆ and Me₂[28]py₂N₆, have been synthesized. The protonation constants of the N-methyl derivative and the stability constants of its complexes with Ni²⁺, Cu²⁺, Zn²⁺, Cd²⁺, and Pb²⁺ were determined at 25 °C in 0.10 mol dm⁻³ KNO₃. The high overall basicity of Me₂[28]py₂N₆ is ascribed to the weaker repulsion between protonated contiguous charged ammonium sites separated by propyl chains. These studies together with NMR, UV-vis and EPR spectroscopies indicated the presence of mono- and di-nuclear species. The single crystal structure of the complex [Ni₂([28]py₂N₆)(H₂O)₄]Cl₄·3H₂O was determined, and showed each nickel centre in a distorted octahedral co-ordination environment. The nickel centres are held within the macrocycle at a large distance of 6.991(8) Å from each other. The formation of mononuclear complexes was evaluated theoretically via molecular mechanics (MM) and molecular dynamics (MD) calculations and showed that these large macrocycles have sufficient flexibility to encapsulate metal ions with different stereo-electronic sizes. Structures for small and large metal ions are proposed.