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Issue 22, 2003
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Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans

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Abstract

LC-MSn analysis of mycolactone toxin from extracts of Mycobacterium ulcerans has shown that minor co-metabolites, including two previously unreported, differ structurally from mycolactone only in a small portion of the polyketide side-chain.

Graphical abstract: Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans

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Publication details

The article was received on 17 Jul 2003, accepted on 05 Aug 2003 and first published on 20 Oct 2003


Article type: Communication
DOI: 10.1039/B308163J
Citation: Chem. Commun., 2003,0, 2822-2823
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    Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans

    H. Hong, P. J. Gates, J. Staunton, T. Stinear, S. T. Cole, P. F. Leadlay and J. B. Spencer, Chem. Commun., 2003, 0, 2822
    DOI: 10.1039/B308163J

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