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Issue 19, 2003
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Proline-catalysed asymmetric amination of α,α-disubstituted aldehydes: synthesis of configurationally stable enantioenriched α-aminoaldehydes

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Abstract

Proline-catalysed amination of α,α-disubstituted racemic aldehydes with azodicarboxylates proceeds smoothly to give configurationally stable scalemic aldehydes and oxazolidinones in up to 86% ee.

Graphical abstract: Proline-catalysed asymmetric amination of α,α-disubstituted aldehydes: synthesis of configurationally stable enantioenriched α-aminoaldehydes

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Publication details

The article was received on 15 May 2003, accepted on 01 Aug 2003 and first published on 22 Aug 2003


Article type: Communication
DOI: 10.1039/B305465A
Citation: Chem. Commun., 2003,0, 2448-2449
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    Proline-catalysed asymmetric amination of α,α-disubstituted aldehydes: synthesis of configurationally stable enantioenriched α-aminoaldehydes

    H. Vogt, S. Vanderheiden and S. Bräse, Chem. Commun., 2003, 0, 2448
    DOI: 10.1039/B305465A

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